Cushings Syndrome Essay - 816 Words

Cushing’s Syndrome Cushing’s Syndrome is a condition that results from chronic exposure to excessive amounts of glucocorticoids circulating in the blood stream for an extended period of time. The disease was first reported by Harvey Cushing over one hundred years ago, yet the condition still plagues endocrinologists today. Reasons for this difficulty include the vast amount of often vague symptoms that the syndrome presents, most of which are found in a plethora of other conditions as well, combined with the multiple forms that the condition can manifest itself. Symptoms of Cushings Syndrome include, but are not limited to, weight gain, hirutism, easy bruising, hypertension, acne, facial plethora, muscle weakness, striae, depression,†¦show more content†¦With Cushings syndrome, this cycle is disrupted, resulting in an excess of circulating cortisol. There are multiple mechanisms that can disrupt the cycle and they can be classified as either ACTH-dependent or ACTH-independent Cushings S yndrome. The most common form of Cushings Syndome is an ACTH-dependent form called Cushings Disease. This type accounts for two thirds of cushings syndrome and is the result of either an adenoma or carcinoma on the pituitary gland. The tumor causes overproduction of ACTH, resulting in increased release of cortisol from the adrenal gland. ACTH- dependent Cushings Syndrome can also result from ectopic tumors that cause overproduction of ACTH or CRH. The most frequent is small-cell lung carcinoma (12% of patients develop Cushings syndrome). A final type of ACTH dependent cushings syndrome is from exogenous ACTH administration, typically the use of synthetic steroids. ACTH-independent Cushings Syndrome typically originates from abnormalities of the adrenal gland. Adrenal adenoma and adrenal carcinoma occur when there is a benign or cancerous tumor on the adrenal gland. These tumors can cause over production of cortisol, disrupting homeostasis. Other diseases like Carney complex and Mc Cune Albright syndrome have also been associated with abnormalities of the adrenal gland, causing overproduction of cortisol. A final form of cushings syndrome is exogenous glucocorticoid administration. The treatment of CushingsShow MoreRelatedThe Relationship Between Cushing Disease And Cushing Syndrome1249 Words   |  5 Pagesmanifest in Cushing disease and Cushing syndrome, with a variety of symptoms, test methods and treatments. It is important to distinguish between Cushing disease and Cushing syndrome. While both are based on high levels of cortisol circulating in the body, Cushing disease is specifically caused by a generally benign tumor of the pituitary gland which secretes excess levels of adrenocorticotropic hormone (ACTH), leading to overproduction of cortisol in the adrenal glands. Cushing syndrome, on the otherRead MoreA Study On Cushing s Syndrome1708 Words   |  7 PagesCushing’s syndrome, also known as hypercortisolism is a rare disease, which develop very high levels of a hormone called cortisol in the body. The syndrome was discovered by Harvey Cushing in 1932. Cushing’s disease, which is a form of Cushing’s syndrome, is responsible for increased morbidity and mortality and the signs and symptoms of that disease are usually non specific and that is why the person with those signs has to do some several tests to find out. It can cause a lot of problems to theRead MoreS ymptoms And Symptoms Of Cushing s Syndrome1680 Words   |  7 PagesAbstract Cushing’s syndrome is an endocrine disorder resulting from excess levels of cortisol in the blood. The etiology can be exogenous or endogenous, which can be further broken down into adrenocorticotropic hormone (ACTH) dependent and independent. The pathogenesis of Cushing’s syndrome depends on the cause, and generally results in the disruption of the normal functioning of the hypothalamic-pituitary-adrenal (HPA) axis. Cushing’s syndrome is characterized by a variety of signs and symptomsRead MoreAnalysis Of Cushing s Syndrome ( Cs )1558 Words   |  7 PagesCushing’s syndrome (CS) is an endocrine disorder that leads to a lot of symptoms in the human body. A chronic excess of cortisol in the bloodstream characterizes CS. Besides the traditional pathways of treatment (which include surgery, radiotherapy and use of medicines), a new advance in the pharmacological treatment of CS is being tested: Agent LCI699. Recent data ratify that the efficacy and safety of the LCI699 are promising in the reduction of the levels of cortisol. When incorporated to anRead MoreCushing s Syndrome : Whole Body Impairment1468 Words   |  6 PagesCushing ’s syndrome: Whole-Body Impairment Kim Gaull Rowan University Cushing s syndrome (CS) is characterized by pathologically elevated free glucocorticoid levels. Endogenous hypercortisolism is usually due to ACTH-secreting pituitary corticotropic adenomas and less often due to ectopic ACTH-secreting neuroendocrine neoplasms or ACTH-independent adrenal cortisol hypersecretion (Yaneva, 2010). Cushing s disease occurs infrequently in an inherited setting in both of these conditions (YanevaRead MoreAnalysis Of Cushing s Syndrome ( Cs )1379 Words   |  6 PagesCushing’s syndrome (CS) is a condition whereby there is an excessive amount of glucocorticoids circulating in the human body1. There are two categories of CS, the most common type is exogenous, which is caused by supraphysiological amounts of glucocorticoids from an external source1. The second type is the endogenous CS and is caused by the endogenous over secretion of glucocorticoids by the adrenal glands2. The incidence of any form of CS has been reported to affect between 2-3 million p opulationRead MoreAnalysis Of Cushing s Syndrome And Its Effects On The Body1510 Words   |  7 Pages Cushing’s syndrome is a rare endocrine disorder that occurs when your body is exposed to an overabundance of the hormone cortisol.3 Cortisol is known as the stress hormone. The interruption of cortisol secretion can cause weight gain and can ultimately determine where you put the weight on.8 There are many underlying causes such as Pituitary Adenomas, Ectopic ACTH Syndrome, Adrenal Tumors, and Familial Cushing’s Syndrome.2 The majority of these people affected by this hormonal disorder experienceRead MoreIntroduction: Striae distensae, commonly referred to as ‘stretch marks’, is an extremely common800 Words   |  4 Pagespresent in areas of maximum skin stretching, research has determined that there is no correlation between the extent of striae formation and the degree of body size expansion during pregnancy. In the case of people with Cushing syndrome, Ehlers-Danlos syndrome, Marfan’s syndrome, increased adrenal cortical activity has been implicated in the formation of striae. Others suggested that SDs are a feature of high serum levels of steroid hormones induced from local or systemic steroid therapy or CushingsRead MoreA Brief Article On Ovary Syndrome ( Pcos )1654 Words   |  7 PagesPolycystic Ovary Syndrome (PCOS) By Navodita Maurice | Submitted On September 01, 2011 Recommend Article Article Comments Print Article Share this article on Facebook Share this article on Twitter Share this article on Google+ Share this article on Linkedin Share this article on StumbleUpon 1 Share this article on Delicious Share this article on Digg Share this article on Reddit Share this article on Pinterest Expert Author Navodita Maurice The endocrine disorders among females are of variousRead MoreHesi Practice31088 Words   |  125 PagesIneffective coping. B. Imbalanced nutrition: Less than body requirements. C. Imbalaneed nutrition: More than body requirements. D. Interrupted family processes. 5. The nurse is caring for a client who underwent a subtotal gastrectomy. To manage dumping syndrome, the nurse should advise the client to A. restrict fluid intake to 1 qt (1,000 mL)/day. B. drink liquids only with meals. C. don t drink liquids 2 hours before meals. D. drink liquids only between meals. 6. A client seeks care for low back pain